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The dynamic field of molecular biology and neuroscience constantly seeks innovative tools to unravel complex cellular processes. Among these, Cdk5 peptide and its derivatives have emerged as crucial agents for studying Cyclin-Dependent Kinase 5 (CDK5), a key enzyme implicated in a variety of cellular functions, particularly neuronal development and function. For researchers looking to advance their investigations, understanding where to find and how to utilize Cdk5 peptide for sale is paramount. This article delves into the specifics of these peptides, their applications, and considerations for purchasing, ensuring you can confidently integrate them into your research.

Understanding Cdk5 and its Peptide Variants

CDK5 is a serine/threonine kinase that plays a critical role in neuronal migration, differentiation, and survival. Its activity is tightly regulated by its regulatory subunits, p35 and p39. Dysregulation of CDK5 activity has been linked to various neurodegenerative diseases, making it a significant target for therapeutic research.

Cdk5 peptides are synthesized molecules that mimic or interfere with the natural functions of CDK5 or its substrates. These peptides are invaluable tools for:

* Inhibiting Cdk5 activity: Cdk5i peptide, for instance, is a well-characterized CDK5 inhibitory peptide. It is designed to bind to Cdk5 and disrupt its interaction with its activators, effectively reducing CDK5 kinase activity. This is particularly useful for studying the consequences of CDK5 inhibition in cellular or animal models.

* Studying Cdk5 substrates: Peptides derived from known CDK5 substrates can be used to investigate how CDK5 phosphorylates these targets. For example, the CDK5 Substrate [PKTPKKAKKL] peptide, which is derived from histone H1 peptide sequence, is a prime example. This native peptide is docked in the active site of cyclin-dependent kinase 5, making it a valuable tool for studying substrate recognition and phosphorylation events.

* Developing Cdk5 blocking peptides: CDK5 blocking peptide serves as a control in Western blot analyses or immunoprecipitation assays. By pre-incubating an antibody with the CDK5 blocking peptide, researchers can confirm that the antibody specifically recognizes the CDK5 protein and not other cellular components. This ensures the accuracy and reliability of experimental results.

* Researching Cdk5/p25 complex: The Cdk5/p25 complex is a particularly relevant entity in neurodegenerative conditions. A Cdk5-derived peptide that inhibits Cdk5/p25 activity has shown promise in ameliorating neurodegenerative phenotypes. Such peptides, like the Cdk5i peptide, which interferes with the Cdk5/p25 complex with Kd of 0.17 uM, are crucial for exploring potential therapeutic strategies.

Where to Find Cdk5 Peptide for Sale

The availability of Cdk5 peptide for sale is growing, with several reputable suppliers offering these specialized reagents. When searching for peptides for sale, it is essential to consider factors such as purity, quantity, and the reputation of the vendor.

Several online platforms and specialized chemical suppliers list Cdk5 peptides. You might encounter listings such as:

* Cdk5i peptide: Often available with specific details on its inhibitory potency. Some suppliers may offer a Special Price 188.30 USD for this peptide.

* CDK5 blocking peptide: Available from various manufacturers, with options like Buy CDK5 Blocking Peptide 33R-6331 online. Pricing can vary, with some offering units at approximately $460 for 1 mg.

* CDK5 Substrate peptides: These are typically offered in various quantities, for example, 10mg. $225.00 or with pricing around $595.00 for highly pure versions.

* General peptide suppliers: Many companies specialize in synthesizing custom peptides or offer a broad catalog of research peptides. These can include Buy peptides online services where you can order peptides synthesized to your specifications. Companies like Bio Basic has the capacity to synthesize hundreds of pharmaceutical grade peptides to high standards.

When exploring options, you may find Cdk5 Peptides listed alongside Cdk5 Proteins. It is important to clarify whether you require a peptide or a full protein for your application.

Purchasing Considerations and Verifiable Information

When purchasing Cdk5 peptide for sale, several factors contribute to ensuring you receive a high-quality product for your research:

* Purity: Most peptides for research are expected to have high purity, typically 95% or greater. This ensures that the observed effects are due to the peptide itself and not impurities.

* Quantity and Pricing: Peptides are commonly sold in milligram (mg) quantities. Prices can range significantly based on the peptide sequence, purity, and supplier. For